In the second cosplay, Niko appeared on Bonnie's stream as if sluggish and with a dull, fuzzy look. I think she was like that because she took antidepressants. I remember my condition and the same look from them. I stopped taking them because I didn't like the constantly inhibited state of mind and blurred thinking.

Also, some antidepressants cause hormonal disruptions, which is why you start to get fat.